Plans for the teams taking on rare cancers.
The same engine behind every tier. What changes between them is how much of it you can point at once, who is allowed to use it, and whether a named person stands behind the answer. A hypothesis generator and prioritisation engine, not a diagnostic.
One ladder, from a free benchmark to a named programme.
An academic lab pays per lab, with no seat count, because a research group loses and gains people by design. A commercial buyer pays per seat, or per team with seats included. A programme is one named indication or target, agreed in a project plan, time-boxed, and expandable only by amendment. Research use only: a hypothesis generator and prioritisation engine, not a diagnostic and not a medical device.
Provisional pricing. These numbers are set from published comparables and are not settled. Expect them to move.
Checkout is not open, so nothing here can be bought today and no card is taken anywhere on this site.
Anyone deciding whether Onkydra can answer their question at all.
One seat.
One named academic lab, where no for-profit owns the intellectual property in the work.
€249 a month billed yearly.
No seat count.
One named person at a company, or an academic on a programme whose IP a for-profit owns.
€664 a month billed yearly.
One seat.
A rare-cancer R&D team running more than one candidate at a time.
€1,328 a month billed yearly.
3 seats included. €300 a month per extra seat.
A team betting the next twelve to eighteen months on one target or one indication.
This lists what DIFFERS between two adjacent tiers, in both directions: a commercial seat covers one person where an academic lab covers a whole group, and that shows up here as the reduction it is.
- Indications in scopeRead-only, on the public benchmark → H3 K27M DMG, within its stated scope
- Runs of your ownNot included → Included
- Daily run ceiling4 a day → 5 a day
- Targets under watchNone → 3 targets
- Mechanistic in-silico knockoutNot included → Included
and 8 more differences in the table below.
- People includedUnlimited, in one named lab → 1 named user
- Commercial use of the outputNot included → Included
- Where questions goEmail → Email, plus an onboarding walkthrough
- Invoice and purchase-order billingNot included → Included
- Data-processing agreementTemplate published → Counter-signed
and 1 more difference in the table below.
- Daily run ceiling5 a day → 15 a day
- Targets under watch3 targets → 10 targets
- People included1 named user → 3, then a flat rate for each extra
- Shared programme memoryNot included → In build, not live
- Where questions goEmail, plus an onboarding walkthrough → Email, onboarding, and a quarterly programme review
and 2 more differences in the table below.
- Indications in scopeH3 K27M DMG, within its stated scope → DMG, plus one named indication or target curated for you
- Runs of your ownIncluded → Agreed in the project plan
- Daily run ceiling15 a day → Agreed in the project plan
- Targets under watch10 targets → Agreed in the project plan
- An indication or target curated for youNot included → Included
and 7 more differences in the table below.
Every line, on every tier.
Monthly rates below. Annual billing is 17% off on every tier that has a monthly rate, on the toggle above. Nothing on this page can be bought today.
Indications in scope
One indication is wired today: H3 K27M diffuse midline glioma, on an n=60 anchor pooled from DKFZ and CPTAC via cBioPortal, with 13 driver features and no treatment-response or survival layer. It runs within that stated scope. Every other indication is on the roadmap and the coverage gate refuses it rather than guessing.
- Free
- Read-only, on the public benchmark
- Academic lab
- H3 K27M DMG, within its stated scope
- Commercial seat
- H3 K27M DMG, within its stated scope
- Commercial team
- H3 K27M DMG, within its stated scope
- Programme
- DMG, plus one named indication or target curated for you
Coverage check before you commit
Ask whether Onkydra can answer about a target in an indication and get yes or no with the reason for a no. It is the same gate the run path uses, so a refusal here is the refusal you would get in a run. Available without paying anything, deliberately.
- Free
- Included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Runs of your own
The free tier grants zero compute. That is the step up to any paid tier and there is no softer way to say it.
- Free
- Not included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Agreed in the project plan
Daily run ceiling
A ceiling on spend, not a price basis. Nothing is sold by the run: there is no top-up, no credit pack and no consumable anywhere in checkout, and an exhausted ceiling sells you nothing and waits for the 24-hour window to roll. An abstention is metered on its own counter at three times the allowance, so an honest refusal is never the expensive answer.
- Free
- 4 a day
- Academic lab
- 5 a day
- Commercial seat
- 5 a day
- Commercial team
- 15 a day
- Programme
- Agreed in the project plan
Targets under watch
One slot is one target watched inside one investigation, which is a standing commitment to check evidence on your behalf. The watching itself, weekly re-runs and drift alerts when ClinVar, the dependency rows or the literature move, is in build and is live on no tier today.
- Free
- None
- Academic lab
- 3 targets
- Commercial seat
- 3 targets
- Commercial team
- 10 targets
- Programme
- Agreed in the project plan
Mechanistic in-silico knockout
Real CellOracle knockouts over a DMG regulatory network, served for 45 transcription factors and for ACVR1 through an explicitly labelled bridge to its downstream factors. It abstains for everything else, which is why CDK7, MEK1, PI3K, ONC201 and MENIN get no mechanistic prediction. An uncalibrated ordering signal and never a probability. Identical on every paid tier.
- Free
- Not included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Measured screen evidence
Pooled CRISPR dependency in the six DMG lines from the Childhood Cancer Model Atlas deposit, and 1,430 transcription factors measured in DIPG17 from GSE267415. A screen measures what a cell needs in order to proliferate, which is a different question from what controls its state, and every surface serving one says so. Identical on every paid tier.
- Free
- Not included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Tumour-tile morphology description
MedGemma describes the morphology of an H&E tile: cellularity, nuclear features, architecture. It is asked for a description and never for a diagnosis, a grade or a subtype, and the prompt is fixed server-side so it cannot be asked for one.
- Free
- Not included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
An indication or target curated for you
Curating an indication means building and verifying its anchor cohort, its regulatory network and its screen evidence, then stating what is missing. It is scoped work with a project plan behind it, which is why it is not a monthly add-on at any subscription tier.
- Free
- Not included
- Academic lab
- Not included
- Commercial seat
- Not included
- Commercial team
- Not included
- Programme
- Included
Every claim resolved to a citation
PMIDs and DOIs are resolved against NCBI and CrossRef at run time, and a citation that does not resolve does not reach the output. This is what stops a fabricated reference, and it runs on every tier including the sample report.
- Free
- Included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Retracted sources held, not cited
A cited paper that has been retracted holds the run rather than appearing with a footnote. This has fired on a real run.
- Free
- Included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Evidence class declared on every layer
Measured result, model run, stated rule, or labelled placeholder, named per layer and never upgraded by the report writer. Negative, null and uninterpretable results are preserved rather than dropped.
- Free
- Included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Abstention when the target is out of scope
Onkydra refuses and says why, rather than producing a confident answer about a target it has no grounded evidence for. A refused run does not consume the daily run ceiling.
- Free
- Included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Full artefact export
The complete run artefact, including inputs, tool calls, evidence classes and citations, exportable as JSON so a result can leave the product and be checked by somebody who does not have an account.
- Free
- Not included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Intervals resampled over the real anchor
Every interval is bootstrapped over the 60 real cases, never over the simulated draws. A simulated co-mutation profile is a Monte Carlo draw from one fitted model and is never a patient, which is also why nothing here is ever priced by how many of them a run makes.
- Free
- Included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Prediction frozen before the result is known
The prediction ledger writes a claim, its evidence and its date before anybody knows the answer, so it cannot be edited to fit the outcome afterwards. The ledger is real and no prediction has been resolved yet, because no result has come back.
- Free
- Not included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
The experiment designed with us
On the subscription tiers you decide what to test and you carry the interpretation. On a programme the experiment is specified in the project plan with us before it runs, which is the difference between a tool you operate and an answer somebody stands behind.
- Free
- Not included
- Academic lab
- Not included
- Commercial seat
- Not included
- Commercial team
- Not included
- Programme
- Included
Observed result filed against the prediction
The result that comes back goes into the immutable record against the prediction that preceded it, whether it agrees or not. Resolution is built and has never run, because nobody has returned a result yet, and this table will say so until one does.
- Free
- Not included
- Academic lab
- Self-filed
- Commercial seat
- Self-filed
- Commercial team
- Self-filed
- Programme
- Filed with us, against the project plan
A named person accountable for the answer
The credence-goods literature is the honest framing here: you cannot verify this kind of answer even after delivery, and the two things that make such a market work are liability and verifiability. The subscription tiers sell capability, so you carry the risk of having used it wrongly. The programme tier sells somebody standing behind the answer. Different jobs, which is what makes the multiple coherent instead of insulting.
- Free
- Not included
- Academic lab
- Not included
- Commercial seat
- Not included
- Commercial team
- Not included
- Programme
- Included
People included
The academic tier is priced per lab rather than per person because a research group of three to fifteen churns people by design, and two 10-K filings in this sector state plainly that seat pricing shrinks when a customer loses staff. Charging a lab for that is charging it for being a lab.
- Free
- 1
- Academic lab
- Unlimited, in one named lab
- Commercial seat
- 1 named user
- Commercial team
- 3, then a flat rate for each extra
- Programme
- Agreed in the project plan
Shared programme memory
IN BUILD, LIVE ON NO TIER. The workspace is single-user today and there is no team or seat model behind it. It is listed because it is what the team tier is for, and it is marked because nobody should buy it expecting it this month.
- Free
- Not included
- Academic lab
- Not included
- Commercial seat
- Not included
- Commercial team
- In build, not live
- Programme
- In build, not live
Commercial use of the output
The academic tier is fenced on employer and IP ownership rather than on an email domain. Work inside your employment at a for-profit, and contract research where a for-profit owns the intellectual property, both need a commercial licence even when the person doing it sits in a university.
- Free
- Not included
- Academic lab
- Not included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Where questions go
All customer-facing founder time comes out of one weekly ceiling, and support and scientific authoring draw on the same hours. The ceiling is a stated decision rather than a measurement, because there are no customers to measure. It is published so that a promise this product cannot keep is visible before you buy rather than after.
- Free
- Public docs and the capability register
- Academic lab
- Commercial seat
- Email, plus an onboarding walkthrough
- Commercial team
- Email, onboarding, and a quarterly programme review
- Programme
- A named contact, inside the project plan
Founder time is capped, and the cap is published
Five hours a week of customer-facing founder time, in total, across every customer. A ceiling and not a target, and it exists because the alternative failure is invisible: hours quietly leaving the research one reasonable half-hour at a time.
- Free
- Included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Card, monthly, cancel anytime
Monthly billing keeps every transaction under the university purchasing-card limits observed across the institutions checked ($2,500 to $5,000) and under both stated purchase-order floors, so the purchase never has to touch procurement. Watch one clause if you are at a US university: at least one bars services from the card entirely, at any amount.
- Free
- Included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Not included
Annual billing at a discount
Seventeen percent off the monthly rate, billed yearly. It clears the academic purchase-order floor on purpose, for a buyer who would rather pass through procurement once a year than expense a card charge every month.
- Free
- Not included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Annual by default
Invoice and purchase-order billing
The honest upgrade gate for a small commercial buyer. It is not a feature anybody wants: it is something their organisation demands, which is exactly why single sign-on works as a gate for larger vendors and cannot work here, since a solo PI and a three-person team have no identity provider to ask.
- Free
- Not included
- Academic lab
- Not included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Data-processing agreement
The standard template and the sub-processor register are published and readable by anyone. A counter-signed agreement, and a customer-specific annex where one is needed, come with a commercial licence.
- Free
- Template published
- Academic lab
- Template published
- Commercial seat
- Counter-signed
- Commercial team
- Counter-signed, with an annex where needed
- Programme
- Counter-signed, with an annex where needed
Security questionnaire completed
We complete your questionnaire, including the HECVAT that several US universities require before any software is acquired, free items and renewals included. None has been completed yet, because no customer has asked for one.
- Free
- Not included
- Academic lab
- Not included
- Commercial seat
- On request
- Commercial team
- Included
- Programme
- Included
Validated-system documentation
NOT OFFERED AT ANY TIER, and it is in this table so that nobody assumes it comes with the largest one. Onkydra is a hypothesis generator and a prioritisation engine, research use only, and it makes no 21 CFR part 11 or EU Annex 11 claim. If your process needs a validated system, this is not one.
- Free
- Not included
- Academic lab
- Not included
- Commercial seat
- Not included
- Commercial team
- Not included
- Programme
- Not included
Research use only
Not a diagnostic, not a medical device, not a treatment recommender, and not a substitute for wet-lab validation. This does not change at any price, and a tier that relaxed it would be selling something Onkydra is not.
- Free
- Included
- Academic lab
- Included
- Commercial seat
- Included
- Commercial team
- Included
- Programme
- Included
Cohort packs: which indication should we build next?
Every plan ships with the DMG anchor cohort. Diffuse midline glioma is the only indication live today, and it runs within a stated scope: an n=60 anchor, 13 driver features, and no outcome layer. The rest are on the roadmap in the order below. Curating an indication means licensing and validating a whole molecular-profile library, so it is scoped as a programme rather than a monthly add-on. Tell us which one you need and it moves up the queue.
Diffuse midline glioma
IncludedH3 K27M anchor, n=60, DKFZ + CPTAC
Included
Ewing sarcoma
In the queueEWSR1 fusion, adolescent + young-adult anchor
Roadmap
MPNST
In the queueNF1-driven, malignant peripheral nerve sheath
Roadmap
ATRT
In the queueSMARCB1 loss, atypical teratoid rhabdoid
Roadmap
High-risk neuroblastoma
In the queueMYCN-amplified, paediatric
Roadmap
Anaplastic thyroid
In the queueBRAF V600E, TP53 co-mutation
Roadmap
Rhabdomyosarcoma
In the queuePAX-FOXO1 fusion, paediatric
Roadmap
Pediatric AML (KMT2Ar)
In the queueKMT2A-rearranged, infant + paediatric
Roadmap
A pack leaves the queue once its anchor cohort has been curated and validated end-to-end through the run pipeline. Diffuse midline glioma is the only pack live today, and it runs within a stated scope. Every other indication listed here is roadmap, not shipped, and ships in order.
Billed monthly, cancel anytime, no lock-in. Annual is 17% off and is a choice rather than the default, because a monthly transaction is a small one.
Checkout is not open. No card is taken anywhere on this site, and there is no plan to manage from the workspace.
A hypothesis and prioritisation engine. Not a diagnostic, not a treatment recommender, not a medical device.
More on trials, billing, and commercial terms in the pricing FAQ.
Get early access to Onkydra.
Onkydra is in private beta and the workspace is open to one address. Join the waitlist and we will reach out with a first run for your programme when it opens to biotech and research teams working on rare cancers.